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What types of sedation are used in pediatric dentistry?
July 12, 202610 min read

What types of sedation are used in pediatric dentistry?

Sedation in pediatric dentistry is the use of medicines that help a child relax, feel less afraid and cope better with dental treatment. The dentist aims to keep the child’s own breathing and protective reflexes intact, while pain is relieved with local anesthesia or other methods.

Before any sedation, the dentist or anesthesiologist assesses the child’s general health and airway features (tonsils, nasal breathing, anatomy), checks medications and allergies, and makes sure the fasting period is observed if deeper sedation is planned.

Main types of sedation at the dentist

  • Minimal sedationthe child is conscious, responds and breathes independently
  • Moderate sedationthe child is drowsy and responds less actively, but breathing is maintained
  • Deep sedation and general anesthesiathe child is asleep and may need help with breathing and monitoring in an operating room setting

1. Nitrous oxide sedation (“laughing gas”)

  • The child wears a special nasal mask and breathes a mixture of oxygen and nitrous oxide through it
  • The effect comes quickly: within 30–60 seconds the child becomes calmer and more relaxed but stays conscious
  • After the procedure the child breathes pure oxygen for a few minutes so that the gas is fully cleared and there is no dizziness
  • The method suits mildly and moderately painful procedures, but it is almost always combined with local anesthesia

2. “Laughing gas” + oral midazolam

One of the best-studied and recommended options when a child is very anxious or not fully cooperative. First, the child is given midazolam syrup 20–30 minutes before the procedure, then the nitrous oxide mask is applied. This combination increases the chance of successful sedation, especially in children aged 4–6. The child is usually relaxed and may be drowsy but breathes independently.

3. Combined sedation with midazolam + dexmedetomidine

This regimen is more often used in children who are very frightened, hard to engage or have had a negative treatment experience. Midazolam is given by mouth (syrup) and dexmedetomidine is usually given intranasally. Sedation starts within 15–20 minutes; the child becomes calmer and sometimes falls asleep. Breathing is monitored by an anesthesiologist or a specially trained doctor.

4. Intravenous sedation and general anesthesia

Sometimes a child flatly refuses dental treatment: cries hard, will not open the mouth, and there is a risk of physical injury or psychological trauma. In such cases dentists, together with anesthesiologists, offer treatment under intravenous sedation or general anesthesia. The medicines are given through a vein, the child falls asleep, and breathing and the cardiovascular system are monitored with special equipment. This treatment takes place in an operating room or a specially equipped room with full monitoring and resuscitation support.

What parents should pay attention to

  • Do not hesitate to ask about the licence and training of the doctor providing sedation
  • Find out who will monitor the child and who will treat the teeth: these must be two separate specialists
  • Tell the doctor about any chronic conditions, episodes of sleep apnea, heart and lung problems and allergies
  • Follow the recommendations on fasting and on what to do after the procedure

Sources

  1. 1.Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures: Update 2016. Pediatric Dentistry, 2018.
  2. 2.The relationship between nitrous oxide sedation and psychosocial factors in the pediatric outpatient setting. Paediatric Anaesthesia, 2022. Moharrami M, Ali S, Dick BD, Moeinvaziri F, Amin M.
  3. 3.Conscious sedation in pediatric dentistry. A short review of the current UK guidelines and the technique of inhalational sedation with nitrous oxide. Paediatric Anaesthesia, 2008. Holroyd I.
  4. 4.Procedural Sedation and Analgesia in Children. Lancet, 2006. Krauss B, Green SM.
  5. 5.Evaluating the Quality of Systematic Reviews on Pediatric Sedation in Dentistry: An Umbrella Review. Journal of Clinical Medicine, 2024. Marques C, Dinis M, Machado V, Botelho J, Lopes LB.
  6. 6.Midazolam Hydrochloride. FDA Drug Label. Food and Drug Administration. Updated April 29, 2025.
  7. 7.Outcomes of Moderate Sedation in Paediatric Dental Patients. Australian Dental Journal, 2012. Özen B, Malamed SF, Cetiner S, et al.
  8. 8.Oral Midazolam vs. Intranasal Dexmedetomidine Plus Oral Midazolam for Sedation of Pediatric Outpatients: A Double-Blinded Randomized Controlled Trial. BMC Anesthesiology, 2023. Nie J, Chen C, Xie J, Ding G.
  9. 9.Comparative Sedative Effects of Intravenous Etomidate/Fentanyl/Midazolam Versus Propofol/Fentanyl/Midazolam Combination for Dental Treatment of Uncooperative Children: A Randomized Clinical Trial. Scientific Reports, 2026. Mozafar S, Ghajari MF, Zarch AE, et al.
  10. 10.Comparison of different sedatives in children before general anaesthesia for selective surgery: A network meta-analysis. Journal of Clinical Pharmacy and Therapeutics, 2022. Yang CQ, Yu KH, Huang RR, et al.
  11. 11.Emergence Delirium in Children: An Update. Current Opinion in Anaesthesiology, 2014. Dahmani S, Delivet H, Hilly J.
  12. 12.Prediction of EEG-Derived Wavelet Index for End-Tidal Sevoflurane in Pediatric Anesthesia: A Prospective, Single-Blind Study. Paediatric Anaesthesia, 2025. Jiang J, Dan Y, Huang Y, Zheng J, Zhang K.
  13. 13.Comparison of low-fresh gas flow technique to standard technique of sevoflurane induction in children — A randomized controlled trial. Paediatric Anaesthesia, 2019.

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